Figure 6.

Spontaneous IJP are MRS2500 sensitive in wild-type mice and completely absent in P2Y₁ KO mice. Frequency distribution of the RMP fully supports these results. In the frequency distribution of recordings from wild-type animals, ongoing sIJP create a tail towards the most negative values. This tail does not appear in the frequency distribution obtained from tissue incubated with MRS2500 or from P2Y₁ KO mice. L-NNA-treated tissue (not shown) depolarizes smooth muscle cells without changing the internal frequency distribution, which is consistent with the presence of spontaneous IJP.