Figure 2.

NS15370 and ML213 cause a vasorelaxation in different precontracted rat blood vessels. (A) Representative effect of increasing concentrations of NS15370 on a segment of small mesenteric artery mounted in a wire myograph precontracted with 10 μM methoxamine. (B) Concentration–effect curves for ML213 and NS15370 on (i) small mesenteric arteries, (ii) thoracic aorta and (iii) renal arteries. Each point is the mean of 7–10 animals ± SEM. A Bonferroni post hoc test was performed following a two-way anova and *** P < 0.001.