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. 2014 Aug 29;171(19):4455–4463. doi: 10.1111/bph.12788

Figure 5.

Figure 5

Analysis of window currents in whole-cell voltage-clamp configuration of NaV1.7-expressing HEK293 cells. Combined superimposed fitted curves of steady-state activation and fast inactivation kinetics in cells expressing NaV1.7 channels (controls or L858F mutant) with NaVβ1 and NaVβ2 subunits. Window currents of cell population expressing wild-type channels (green striped area) were reduced by mexiletine (500 μM; green solid area). Mexiletine treatment (500 μM; red solid area) also reduced window currents of cells expressing L858F mutant channels (red striped area). All data are presented are as means.