Figure 5.

Analysis of window currents in whole-cell voltage-clamp configuration of Na_V1.7-expressing HEK293 cells. Combined superimposed fitted curves of steady-state activation and fast inactivation kinetics in cells expressing Na_V1.7 channels (controls or L858F mutant) with Na_Vβ1 and Na_Vβ2 subunits. Window currents of cell population expressing wild-type channels (green striped area) were reduced by mexiletine (500 μM; green solid area). Mexiletine treatment (500 μM; red solid area) also reduced window currents of cells expressing L858F mutant channels (red striped area). All data are presented are as means.