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Cell and recording properties
| Peak current (nA) | Whole-cell capacity (pF) | Series resistance (MΩ) | |
|---|---|---|---|
| Controls (n = 29) | −0.68 (0.09) | 16.8 (1.88) | 12.7 (1.22) |
| L858F (n = 35) | −0.53 (0.08) | 22.7 (1.90) | 16.4 (1.99) |
| P value | 0.08 (ns) | 0.12 (ns) | 0.11 (ns) |
Data presented as mean values and SEM. Differences in means of cells with NaV1.7 L858F mutant channels compared with NaV1.7 wild-type controls were tested by Student’s two-tailed t-test. P < 0.05 was considered significant.
