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. 2014 Sep 5;171(19):4478–4489. doi: 10.1111/bph.12800

Figure 4.

Figure 4

Clofoctol inhibits prostate cancer growth through induction of ER stress. (A) PC3 cells were grown in 96-well plates and treated with 20 μM clofoctol and 2 mM phenylbutyrate (PheB) for 72 h. An AlamarBlue assay was conducted to assess the cell viability. Data represent mean ± 95% confidence interval from three independent experiments (**P < 0.001). (B) PC3 cells were treated with the indicated concentrations of phenylbutyrate (PheB) and clofoctol for 24 h. Cells were then harvested for Western blot analysis of phosphorylated eIF2α and CHOP.