Extended Data Figure 4. δ-cells dedifferentiate, proliferate and reprogram into insulin production after extreme β-cell loss in juvenile mice.

Observed and expected numbers of somatostatin⁺ and insulin⁺ cells per islet section, before and after β-cell ablation. Cells scored after 6 weeks (Extended Data Fig. 3a) correspond (χ² test) with estimates made assuming that dedifferentiated proliferating δ-cells yield 2 types of progeny (as deduced from Fig. 2c,e). Dashed arrows, phenotypic stability; plain arrows, dynamic behavior (dedifferentiation and replication).