Table 1.

Glaucoma Status Prediction with Univariable and Multivariable Models of GDx and FDT

Glaucoma group	Model	AIC	AUC	Sensitivity	Specificity	CC*	PIL*
All	NFI**	120.88	0.914	87.8	84.2	86.5	0.180
	TSNIT	126.58	0.902	79.7	93.4	82.4	0.189
	NAP-FDT	129.12	0.881	83.8	86.8	78.4	0.165
	FDT	129.00	0.853	83.8	86.8	78.4	0.163
	CDR	102.90	0.931	93.2	81.6	85.1	0.137
	Multivariable	88.28	0.959	94.6	89.5	83.8	0.147
Early	NFI**	102.26	0.872	87.9	80.3	80.4	0.178
	TSNIT	101.40	0.854	72.7	86.8	76.8	0.199
	NAP-FDT	109.98	0.796	69.7	86.8	71.4	0.162
	FDT	103.67	0.783	69.7	86.8	71.4	0.155
	CDR	79.32	0.908	87.9	81.6	80.4	0.186
	Multivariable	76.06	0.930	87.9	89.5	82.1	0.240
Moderate	NFI**	44.16	0.961	95.8	92.1	95.2	0.105
	TSNIT	49.49	0.946	91.7	94.7	92.9	0.124
	NAP-FDT	55.56	0.929	91.7	92.1	81.0	0.104
	FDT	61.80	0.893	91.7	86.8	71.4	0.155
	CDR	50.99	0.936	91.7	90.8	92.9	0.112
	Multivariable	39.37	0.983	100	88.2	83.3	0.125
Severe	NFI	39.14	0.931	88.2	94.7	100	0.106
	TSNIT	44.12	0.932	94.1	93.4	93.2	0.134
	NAP-FDT**	36.48	0.976	94.1	97.4	88.6	0.079
	FDT	38.07	0.934	100	86.8	77.3	0.110
	CDR	37.13	0.968	100	81.6	84.1	0.122
	Multivariable	30.62	0.986	100	92.1	88.6	0.121

AIC, Akaike’s information criterion; AUC, area under the curve; CC, proportion subjects correctly classified; PIL, median prediction interval length; NFI, nerve fiber indicator; TSNIT, average RNFL; NAP-FDT, number of abnormal points on FDT; FDT, normal or abnormal; CDR, cup-to-disc ratio.

^*Calculated using the validation set;

^**Best single variable model