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. Author manuscript; available in PMC: 2015 Apr 23.
Published in final edited form as: Nature. 2014 Aug 17;514(7523):513–517. doi: 10.1038/nature13605

Extended Data Figure 7. JMJD3 is necessary for disease initiation in an animal model of T-ALL.

Extended Data Figure 7

Initiation of the disease was studied using a transplantation scheme of c-kit hematopoietic progenitors. a, b, Blood analysis of the recipients for Notch1-IC/GFP leukemic blasts (Jmjd3+/− (n=8) and Jmjd3−/− (n=8), a) and white blood cells (WBC, Jmjd3+/− (n=4) and Jmjd3−/− (n=6), b). Comparison of the organs size (c) and histochemistry (H&E) (d) and FACS-based (e) analysis of the leukemic infiltration in the spleen. f, Survival studies of recipients. Eight recipients for Jmjd3+/− and eight for Jmjd3−/− background were used in panels c–f.