Table 5.
Risk factors of reduced transplantation-free survival
| Risk factor | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | HR (CI 95%) | p-value | HR | HR (CI 95%) | p-value | |
| Sex | 0.8 | 0.4-1.6 | 0.5 | 1.2 | 0.5-2.6 | 0.7 |
| Presence of dominant stenosis | 0.5 | 0.2-1.0 | 0.06 | 0.4 | 0.1-1.0 | 0.04 |
| Presence of IBD | 0.5 | 0.2-1.1 | 0.07 | 0.3 | 0.1-0.8 | 0.02 |
| Overlap with autoimmune hepatitis | 0.9 | 0.3-2.8 | 0.8 | 0.4 | 0.1-1.5 | 0.2 |
| Age at PSC diagnosis | 1.0 | 1.0-1.1 | 0.3 | 1.0 | 1.0--1.1 | 0.09 |
| Number of ERCs | 1.0 | 0.9-1.1 | 0.8 | 1.0 | 0.9-1.1 | 0.7 |
| Mayo Risk Score | 1.3 | 1.1-1.7 | 0.02 | 1.4 | 1.1-1.8 | 0.01 |
| Candida | 0.4 | 0.2-0.8 | 0.006 | 0.4 | 0.2-0.8 | 0.008 |
HR, hazard ratio; CI, confidence interval; ERC, endoscopic retrograde cholangiography; IBD, inflammatory bowel disease; PSC, primary sclerosing cholangitis; AIHOLS, autoimmune hepatitis overlap syndrome; DS, dominant stenosis.
The data show prospective factors predictive of longer actuarial transplantation-free survival. In the univariate analysis, the presence of dominant stenosis, number of ERCs, and age at diagnosis of PSC were associated with biliary candidiasis. In the multivariate analysis, only the number of ERCs and age at diagnosis of PSC reached significance (p < 0.05, bold).