Fig. 2.

Pralatrexate (PDX) is more potent than methotrexate and pemetrexed in vitro. Dose response curves shown as percent of viable H2052 mesothelioma cells remaining after 24 h treatment with pralatrexate (a), methotrexate (b) or pemetrexed (c) followed by 72 h culture in fresh media (solid line) or followed by 24 h culture in 2μM leucovorin and 48 h culture in media (dashed line). d A summary table of IC50 values