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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Mutat Res Genet Toxicol Environ Mutagen. 2014 Jun 2;0:46–54. doi: 10.1016/j.mrgentox.2014.04.024

Figure 4.

Figure 4

Photomicrographs of mouse left liver-lobe sections stained with haematoxylin and eosin (H&E). Female B6C3F1 mice were treated by gavage with 0 (A–C) or 15 mg/kg bw furan (D–F) in corn oil. The animals were sacrificed 24 h after receiving a single oral dose (A, D), three weekly doses (B, E) or five daily doses for 6 weeks (C, F). Furan treatment caused hepatocellular necrosis admixed with reactive leukocytes (panel D), an accentuated lobular pattern and minimal sub-capsular hepatocellular necrosis admixed with reactive leukocytes (panel E), and occasional atypical mitotic figures including multipolar mitoses in cytomegalic and normal hepatocytes (Panel F, and Panel F upper inset, respectively), and lag-type mitoses with nonattached condensed chromatin (Panel F, lower inset).