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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Mutat Res Genet Toxicol Environ Mutagen. 2014 Jun 2;0:46–54. doi: 10.1016/j.mrgentox.2014.04.024

Table 1.

Mutant frequency in the cII gene in liver lobes of DMN- and furan-treated Big Blue B6C3F1 female micea.

Treatment Average (×10−5) ± SD N
Positive controlb Control 0.9 ± 0.5 5
DMN 3.0 ± 0.5c 5
Six-week experimentd Control 1.2 ± 0.3 3
Furan 1.2 ± 0.2 5
Three-week experimente Control 1.8 ± 0.5 5
Furan 1.1 ± 0.2 5
a

Data for individual animals are displayed in Supplemental Tables 1–3 and were corrected for the percentage of clonal mutants, with the exception of the DMN-treated group and its control.

b

Groups of five female mice were given four doses of 0 or 4 mg/kg DMN in saline by oral gavage for 4 consecutive days. Mice were sacrificed 10 days after final treatment.

c

Statistically different from controls, p-value < 0.0003.

d

Groups of five mice were given 0 or 15 mg/kg bw furan in corn oil by oral gavage on 5 days per week for 6 weeks. Mice were sacrificed 24 h after the final dose.

e

Groups of five mice were given 0 or 15 mg/kg bw furan in corn oil by oral gavage once weekly for 3 weeks. Mice were sacrificed 1 week after the final dose.