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Schematic TRPV1 protein with 6 transmembrane regions and the intramembrane loop that forms the cation pore. Various ligands are shown. Bradykinin binds to its B2 receptor and activates 12- and 15-lipoxygenase (12-LO, 125-LO) and phospholipase C (PLC) and protein kinase A (PKA) that phosphorylates the carboxy-terminus of the protein. Used with permission of the copyright holder.
