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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: J Mol Neurosci. 2014 Apr 26;54(3):360–369. doi: 10.1007/s12031-014-0308-5

Figure 3.

Figure 3

CYP-induced cystitis increases pJNK expression in detrusor muscle of rat urinary bladder. Fluorescence images of pJNK expression in urinary bladder sections of control (A), 4 hr (B), and 48 hr (C) CYP-treated rats. For all images, exposure times were held constant, and all tissues were processed simultaneously. In control rats, little if any pJNK expression was visible in the detrusor (A). CYP treatment (4 hr, B; 48 h, C) upregulated expression of pJNK in the detrusor. D. Intravesical instillation of SP600125 (25 μM) to block JNK phosphorylation reduced pJNK expression in the detrusor of rats treated with CYP (4 hr). J: summary histogram of pJNK expression in the detrusor with CYP treatment expressed a percentage of pJNK expression above threshold and averaged for all bladders from all conditions examined (n = 6). *P ≤ 0.01. Calibration bar represents 50 μm.