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SF1-CB1-KO mice are obesity-prone when chronically exposed to a mild HFD. (A) Weekly body weight gain, (B) fat mass and (C) lean mass in male SF1-CB1-WT and SF1-CB1-KO littermates maintained on HFD for 8 weeks (n = 6–10). (D) Glucose tolerance test and (E) insulin tolerance test carried out in male SF1-CB1-WT and SF1-CB1-KO mice maintained on HFD for 8 weeks (n = 10–14). Data are represented as mean ± SEM. *P < 0.05; #P < 0.05 genotype effect.
