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. 2014 Jul 29;3(7):770–777. doi: 10.1016/j.molmet.2014.07.006

Figure 2.

Figure 2

(A) Putative FoxO1 binding sites in the Dbh promoter in human, mouse, rat, horse, dog, chicken and zebrafish. (B) Binding of FoxO1 to the Dbh promoter detected by Chromatin immuno-precipitation (ChIP) assay. (C) DNA cotransfections assays in HEK cells using a FoxO1 expression vector and reporter vectors containing fragments of Dbh promoter fused to the Luciferase gene. (D) Dbh expression in FoxO1fl/fl and FoxO1Dbh−/− brainstem. (E) In situ hybridization analysis of the Dbh expression in the locus coeruleus, adrenal gland, the dorsal root ganglion, and superior cervical ganglion.