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Combination effect of co-depletion of IMPDH2 and SIRT1 on INZ induced cell death. HCT116 cells, transfected with scrambled siRNA (SiControl), IMPDH2 siRNA (SiIMPDH2), SIRT1 siRNA (SiSIRT1) or co-transfected with IMPDH2 and SIRT1 siRNA, were treated with different doses of INZ and cell viability were assessed by WST cell growth assays. IC50 values are represented as mean ± standard deviation (n=3).
