| Pre-invasive lesions |
Pre-invasive lesions |
Preinvasive lesions |
| ➢ Atypical adenomatous hyperplasia (AAH) (≤0.5 cm) |
➢ Atypical adenomatous hyperplasia (AAH) (≤0.5 cm) |
➢ Adenocarcinoma in situ (≤0.5 cm; formerly AAH) |
|
➢ Adenocarcinoma in situ (AIS) (≤3 cm; formerly BAC) |
|
| Adenocarcinoma |
Invasive adenocarcinoma |
Invasive adenocarcinoma |
| ➢ Mixed subtype |
➢ Mininmally invasive adenocarcinoma (MIA; ≤3 cm bronchioloalveolar predominant tumor with ≤5 mm invasion) |
➢ Growth patterns in approximate % |
| ➢ Acinar adenocarcinoma |
➢ Lepidic predominant (formerly nonmucinous BAC pattern, with >5 mm invasion) |
|
| ➢ Papillary adenocarcinoma |
➢ Acinar predominant |
|
| ➢ Bronchioloalveolar carcinoma |
➢ Papillary predominant |
|
| ▪ Nonmucinous |
➢ Micropapillary predominant |
|
| ▪ Mucinous |
➢ Solid predominant with mucin production |
|
| ▪ Mixed nonmucinous and mucinous or indeterminate |
|
|
| ➢ Solid adenocarcinoma with mucin production |
|
|
| Variants of adenocarcinoma |
Variants of invasive adenocarcinoma |
|
| ➢ Fetal adenocarcinoma |
➢ Invasive mucinous adenocarcinoma (formerly mucinous BAC) |
| ➢ Mucinous (“colloid”) carcinoma |
➢ Colloid |
| ➢ Mucinous cystadenocarcinoma |
➢ Fetal (low and high grade) |
| ➢ Signet ring adenocarcinoma |
➢ Enteric |
| ➢ Clear cell adenocarcinoma |
|
