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. Author manuscript; available in PMC: 2014 Oct 27.
Published in final edited form as: J Cell Physiol. 2008 Sep;216(3):824–834. doi: 10.1002/jcp.21462

Fig. 1.

Fig. 1

Exogenous soluble rmNetrin-1 affects the morphology and differentiation of TEBs in mammary glands of MMTV-CR-1 transgenic mice. When compared to normal TEBs of MMTV-CR-1 transgenic mice containing the control cholesterol only releasing pellets (A), the TEBs of the MMTV-CR-1 transgenic mice treated with the rmNetrin-1 releasing pellets show multiple, alveolar-like structures (B and boxes in D, F). Parts (C,D) show the distribution of myoepithelial cells as determined by immunostaining for CK14. Immunostaining for the luminal cell marker CK8 showed weak staining in the TEBs of the MMTV-CR-1 control mice (E) and strong staining in the TEBs of the Netrin-1 treated MMTV-CR-1 transgenic mice (F) suggesting an alveolar-like differentiation (CK14+; CK8+) within the TEBs of the Netrin-1 treated MMTV-CR-1 transgenic mice.