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. 2014 Oct 26;6(10):1049–1059. doi: 10.4330/wjc.v6.i10.1049

Figure 2.

Figure 2

Secondary structures of the ATP-binding cassette transporter A1, ATP-binding cassette G1 and ATP-binding cassette G4 transporters. The ATP-binding cassette transporters (ABC)A1 transporter comprises 2201 amino acids with two transmembrane domains comprising two nucleotide binding domains (NBD-1 and -2) and six transmembrane helices, which contain two conserved peptide motifs, Walker-A and -B. ABCA1 is characterized as two large extracellular loops and N-terminus oriented towards the cytosol. Both ABCG1 and ABCG4 proteins have one transmembrane domain comprising six transmembrane helices and one NBD that contains two conserved peptide motifs, Walker-A and Walker-B.