Table 2.

Multivariable-Adjusted Mean (95% CI) Trait Score Change Associated with a 1-Quintile Baseline Difference in BMI or/and Fasting Insulin, or/and a 1-Quintile Change in BMI or/and Fasting Insulin over 7-years

		Outcome: multivariable-adjusted mean (95% CI) trait score change
Predictor variables	1-quintile baseline difference or/and 1-quintile 7-year change in predictor variable considered	All predictors modeled individually in these columns				Predictors modeled in pairs		All 4 predictors modeled together
BMI	Baseline difference	0.10 (0.08–0.13)				0.14 (0.12–0.17)		0.07 (0.04–0.10)
	7-year change		0.23 (0.19–0.28)			0.30 (0.25–0.34)		0.21 (0.16–0.26)
Fasting insulin	Baseline difference			0.09 (0.06–0.12)			0.22 (0.19–0.25)	0.18 (0.15–0.21)
	7-year change				0.12 (0.10–0.15)		0.23 (0.20–0.25)	0.18 (0.15–0.21)

All trait score change P values<0.0001 for the test that trait score change=0.

All models are adjusted for age, sex, and baseline cluster score.

In models that included individual predictors, the trait score change assoicated with a 1-quintile difference in baseline BMI was 0.10 traits, and with a 1-quintile 7-year change in BMI was 0.23 traits, and with a 1-quintile difference in fasting insulin was 0.09 traits, and with a 1-quintile change in fasting insulin was 0.12 traits. In a model that included both baseline BMI and 7-year change in BMI, the trait score change associated with a 1-quintile difference in baseline BMI was 0.14 traits and for 7-year change in BMI was 0.3 traits. Similarly, in a model that included both baseline fasting insulin and 7-year change in fasting insulin, the trait score change associated with a 1-quintile difference in baseline fasting insulin was 0.22 traits and for 7-year change in fasting insulin was 0.23 traits. In a model that included 1-quintile baseline differences and 1-quintile prospective changes in BMI and fasting insulin, all predictors were positively assoicated with trait score change (BMI difference: 0.07 traits, BMI change: 0.21 traits, fasting insulin difference: 0.18 traits and fasting insulin change: 0.18 traits).

CI, confidence interval; BMI, body mass index.