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. 2014 Oct 20;11:24. doi: 10.1186/2045-8118-11-24

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Copyright © 2014 Anderson et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Data workflow: (Left, top) FLAIR images were linearly registered to high-resolution MPRAGE space using rigid body registration. (Left, lower) Co-registered R₁ maps were prepared in high-resolution MPRAGE space after alignment of all variable-TI MPRAGE images to the TI 1800 image collected at the temporal mid-point of CR washout (see Methods for additional details). (Right) Fractional blood volume (v_b) maps of pWMHs and dWMHs and corresponding FLAIR image. Insets show a magnified view of the WMHs (outlined in white) with associated color scales. The v_b histograms of each WMH are also shown.