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Critical interplay between the pancreatic cancer cells and the microenvironment. TGF-β: Transforming growth factor-beta; VEGF: Vascular endothelial growth factor; HGF: Hepatocyte growth factor; SHH: Sonic hedgehog; EGF: Epidermal growth factor; FGF: Fibroblast growth factor; IGF: Insulin-like growth factor; MMP: Matrix metalloprotease; PDGF: Platelet derived growth factor.
