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Protumorigenic role of osteopontin in pancreatic cancer development and progression. Osteopontin (OPN) expression in pancreatic cancer cell lines is associated with increased in vitro proliferation and enhanced growth and metastasis in vivo, which are reversed by OPN knockdown, OPN RNAi and anti-OPN antibody. Exposure to cigarette smoke (including nicotine) and hepatocytes induce OPN expression.
