Table 1.

Dysregulated microRNAs in resistant cells: Microarray results

	EAC			ESCC
	miRNA	Stepup P-value	Fold-change	miRNA	Stepup P-value	Fold-change
Dysregulated microRNAs in cisplatin-resistant variants	miR-181a-5p	0.00141	-1.78	miR-320a	0.002	-1.75
	miR-125a-5p	0.00169	-2.23	miR-320b	0.002	-1.76
	let-7e-5p	0.00170	-2.21	miR-320c	0.002	-1.66
	miR-181b-5p	0.00170	-1.68	miR-744-5p	0.023	-1.90
	miR-200b-3p	0.00170	-5.38	miR-99b-5p	0.023	-1.70
	miR-31-5p	0.00188	-1.57	miR-92a-3p	0.030	-1.53
	miR-200b-5p	0.00278	-5.11	miR-25-5p	0.041	-2.52
	miR-455-3p	0.00510	-2.78	miR-339-5p	0.047	-1.60
	miR-191-5p	0.00934	1.30	miR-18a-3p	0.056	-2.42
	miR-638	0.00934	1.74	miR-193b-3p	0.062	-1.73
	miR-92b-5p	0.01344	1.79	miR-130a-3p	0.077	2.28
	miR-23a-3p	0.01799	-2.31
	miR-200a-3p	0.03240	-5.05
	miR-296-3p	0.04236	1.66
	let-7a-5p	0.04236	-1.87
	miR-203a	0.04236	-2.84
	miR-663a	0.04480	2.40
	miR-532-5p	0.04913	-2.44
Dysregulated microRNAs in 5-FU-resistant variants	miR-31-5p	0.00031	1.84	miR-550 a-5p	0.001	3.23
	miR-192-5p	0.00151	-2.57	miR-935	0.008	-3.69
	miR-194-5p	0.00151	-2.55	miR-550 a-3p	0.037	2.65
	miR-378 a-3p	0.00277	-3.17	miR-99b-5p	0.045	-1.70
	miR-222-3p	0.00277	2.06	miR-18a-3p	0.047	-2.71
	miR-210-3p	0.00289	-2.90	miR-1226-3p	0.072	-2.45
	miR-18a-3p	0.00456	-1.84	miR-1292-5p	0.072	1.77
	miR-21-3p	0.00556	2.53	miR-125a-5p	0.127	-1.92
	miR-1268a	0.00880	2.95	miR-410-3p	0.233	-1.46
	miR-25-5p	0.01189	2.21	miR-331-3p	0.240	-2.21
	miR-27b-3p	0.01797	-2.12	miR-663a	0.240	-2.61
	miR-17-5p	0.01928	-1.35	miR-196b-5p	0.251	-2.58
	miR-193b-3p	0.01961	3.78
	miR-17-3p	0.03118	-3.03
	miR-455-5p	0.03143	-1.40
	miR-1275	0.03143	3.29
	miR-203a	0.03456	-2.85
	miR-663a	0.04074	2.39

Summary of miRNA microarray results for the different chemotherapy resistant cell lines, including dysregulated miRNAs, stepup P-value and fold changes in expression, compared to sensitive controls. FU: 5-FU resistant cells; EAC: Esophageal adenocarcinoma cells; ESCC: Esophageal squamous cell carcinoma cells.