Table 1.

National Comprehensive Cancer Network criteria for familial breast cancer

Family History
• Early-age-onset breast cancer
• Two breast primaries or breast and ovarian/fallopian tube/primary peritoneal cancer in a single individual or two or more breast primaries or breast and ovarian/fallopian tube/primary peritoneal cancers in close relative(s) from the same side of family (maternal or paternal)
• A combination of breast cancer with one or more of the following: Thyroid cancer, sarcoma, adrenocortical carcinoma, endometrial cancer, pancreatic cancer, brain tumors, diffuse gastric cancer, dermatologic manifestations or leukemia/lymphoma on the same side of family
• Member of a family with a known mutation in a breast cancer susceptibility gene
• Populations at risk
• Male breast cancer
• Ovarian/fallopian tube/primary peritoneal cancer
Known BRCA1/2, p53, PTEN, or other gene mutation associated with breast cancer risk