Fig. 1. Prognostic significance of TMEPAI expression in metastatic breast cancer patients and its TGF-β dependent induction in breast cancer cells.
A) Kaplan-Meier curves representing the probability of recurrence-free survival of ER negative and Lymph Node positive breast cancer patients using a publicly accessible database and an online tool [22]. B) Dose dependent expression of TMEPAI protein in MDA-MB-231 triple negative breast cancer cells after 24h treatment with different doses of TGF-β. C) Time dependent expression of TMEPAI protein after treating MDA-MB-231 cells with 0.1 ng/ml of TGF-β. Growth curves of MDA-MB-231 cells (D) and HMEC (E) cells in the absence or presence of TGF-β (2 ng/ml) and SB431542 (2μM), a TGF-β RI kinase inhibitor. Inset shows relative expression of TMEPAI protein.
