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. 2014 Sep;5(9-10):320–336. doi: 10.18632/genesandcancer.30

Fig. 8. Role of TMEPAI-PTEN axis in promoting Snai1 expression in breast cancer cells.

Fig. 8

Relative expression of Snail1 and TMEPAI proteins (A) and mRNAs (B) in MDA-MB-231 cells expressing control and TMEPAI shRNA without or with TGF-β (2 ng/ml). C) Effect of PI3K inhibitor, LY294002 (10μM) on Snail1 expression and Akt activation (phospho Akt; pAkt) in MDA-MB-231 cells without or with TGF-β (2 ng/ml) stimulation. D) Effect of wild type (Wt) and mutated (C124S, G129E) PTEN, expressed by Adenoviruses, on CON shRNA and TMEPAI shRNA expressing MDA-MB-231 cells for the expression of Snail1, pAkt, pGSK-3β, PTEN and GAPDH. EV: Empty virus.