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. 2014 Sep;5(9-10):348–352. doi: 10.18632/genesandcancer.32

Figure 1. Alcohol- and LPS-treated mice develop aggressive lymphoma.

Figure 1

(A) Mice fed with a Lieber DeCarli-based diet with 6.7% ethanol and treated with intraperitoneal injections of low dose LPS (2mg/kg) develop aggressive lymphomas (arrows, left panel), accompanied by massive thoracic and abdominal hemorrhages (right panel). (B-E) The lymphoma involves non-lymphoid tissue. H&E staining with several tissues such as liver (WT) (B), kidney (Smad3+/−) (C), pancreas (Sptbn1+/−) (D), and lung (Sptbn1+/−/Smad3+/−) (E). Insets: 2× magnification of the areas selectedby dashed rectangles.