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. Author manuscript; available in PMC: 2014 Oct 27.
Published in final edited form as: Arch Biochem Biophys. 2012 May 22;526(2):107–113. doi: 10.1016/j.abb.2012.05.007

Figure 4. Cartoon of epitopes of internalizing phage antibodies binding HER2 and EphA2.

Figure 4

Left panel: Epitopes of F5 phage antibody and 4D5 Fab (Herceptin epitope). F5 binds the most membrane distal domain 1. Right panel: Epitopes of internalizing EphA2 phage antibodies. All phage antibodies compete with ephrin A1 ligand binding and thus bind to the membrane distal ligand-binding domain. The cartoon structures were adopted from PDB file 1N8Z, 2X10, and 3CZU.