Table 1.

Prepulse inhibition and acoustic startle response in rats treated with diazapam, imipramine or valproic acid. Data represented as the mean ± SEM (n=8).

	Avg % PPI (M)	Avg % PPI (F)	Pulse Alone (M)	Pulse Alone (F)
Diazapam
Vehicle	23.3 ± 7.4	20.0 ± 7.5	365.6 ± 61.7	239.9 ± 66.4
1 mg/kg	26.9 ± 7.5	15.0 ± 7.6	270.1 ± 50.3	175.8 ± 19.2
3 mg/kg	28.9 ± 5.4	26.2 ± 6.2	255.1 ± 27.6	188.9 ± 39.9
10 mg/kg	33.6 ± 3.5	27.8 ± 7.7	209.2 ± 23.4	144.3 ± 10.4
Imipramine
Vehicle	23.8 ± 7.8	33.3 ± 7.6	360.0 ± 113.1	367.1 ± 92.9
1 mg/kg	29.5 ± 2.3	32.8 ± 3.2	394.1 ± 128.2	347.6 ± 77.2
3 mg/kg	28.0 ± 8.8	23.9 ± 4.6	197.5 ± 31.1	247.8 ± 50.8
10 mg/kg	33.2 ± 4.4	43.7 ± 5.6	252.1 ± 37.6	329.0 ± 115.1
Valproic Acid
Vehicle	26.2 ± 5.2	21.4 ± 3.1	99.8 ± 22.9	94.0 ± 11.1
50 mg/kg	23.9 ± 5.3	21.8 ± 3.6	117.3 ± 11.1	101.2 ± 9.1
100 mg/kg	33.1 ± 5.1	24.3 ± 5.0	143.9 ± 13.3	126.7 ± 24.8
200 mg/kg	27.5 ± 2.4	24.6 ± 5.1	139.9 ± 24.3	91.4 ± 21.3

Abbreviations: Avg = average, M = male, F = female