Table 4.
Gene-environment interactions with nominal interaction p-value <0.01
| SNP/Chromosomal Location Environmental Variable |
Gene/ Locus |
ORa,b | CI | Nominal p-value |
Adjusted p-value |
pv.het |
|---|---|---|---|---|---|---|
| rs6691170/1q41 PMH use at reference (yes/no) |
DUSP10 | 1.22 | 1.08–1.39 | 1.74 × 10−3 | 0.30 | 0.18 |
| rs3217810/12p13.32c Dietary fiber (per 10 g/day) |
CCND2 | 0.77 | 0.65–0.91 | 2.98 × 10−3 | 0.45 | 0.20 |
| rs3217810/12p13.32c Dietary folate (per 500 mcg/day) |
CCND2 | 0.60 | 0.42–0.85 | 4.11× 10−3 | 0.56 | 0.12 |
| rs7136702/12q13.13c Vegetable consumption (per 5 servings/day) |
LARP4/ DIP2B |
1.28 | 1.07–1.54 | 7.39 × 10−3 | 0.77 | 0.68 |
| rs10936599/3q26.2 Sex (female/male) |
MYNN | 0.86 | 0.77–0.96 | 7.73 × 10−3 | 0.78 | 0.31 |
| rs719725/9p24c Fruit consumption (high vs. low) |
TPD52L3/ IL-33/ UHRF2/ GLDC |
1.10 | 1.02–1.19 | 9.59 × 10−3 | 0.86 | 0.90 |
ABBREVIATIONS: PMH (post-menopausal hormone use); OR (odds ratio)
a
Interaction OR for SNP (log-additive for number of risk alleles) * exposure (as categorized above)
b
Adjusted for age, sex, study center, and population substructure (principal components 1–3)
c
Analyses further adjusted for energy intake (where available)