Table 1.

Baseline characteristics for patients with culture-confirmed pneumococcal meningitis and CSF bacterial load values (n = 102). Multivariate analysis presented for Model 1, clinical parameters with bacterial load data.

Clinical parameter (n = data available)	All participants (SD, IQR or %)	Survivor day 40 (SD, IQR or %)n = 75	Non-survivor day 40 (SD, IQR or %)n = 73	Survival significance (univariate)	Odds ratio (95% CI) bacterial load data Model 1	Survival significance bacterial load model 1 n = 102 (multivariate)
Female gender n = 144	72 (51%)	36 (48%)	36 (49%)	0.4c	2.24 (0.62:8.03)	0.21
Mean age n = 144	32.1 (SD 9.7)	30 (SD 9.1)	33 (SD 10.2)	0.06a	1.02 (0.95:1.09)	0.54
HIV antibody positive n = 141	115 (82%)	60 (80%)	55 (75%)	0.8c	1.43 (0.25:8.2)	0.68
Seizures n = 142	50 (35%)	16 (21%)	34 (47%)	0.002c	7.2 (2.18:23.8)	0.001
Altered mental state GCS <15	111 (81%)	49 (65%)	61 (84%)	<0.001c	4.55 (0.41:51.0)	0.22
Median Glasgow coma score (GCS) n = 137	11 (8–14)	13 (10–15)	9 (7–11)	<0.001b	0.72 (0.59:0.92)	0.001
Dexamethasone n = 89	49/89 (55%)	28 (57%)	21 (43%)	0.36c	0.47 (0.12:1.87)	0.28
Glycerol n = 62	27/62 (46%)	8 (30%)	19 (70%)	0.03c	2.29 (0.4:12.9)	0.34
Mean Haemoglobin (g/dL) n = 129	11.3 (SD 2.9)	11.3 (SD 2.4)	11.4 (SD 3.2)	0.94a	0.82 (0.68:0.98)	0.032
Median CSF white cell count (mm3/ml) n = 143	760 (181–2600)	1120 (320–1320)	370 (105–1480)	0.021b	1.0 (1.0–1.0)	0.91
Median CSF bacterial load (DNA copies/ml) with IQR
Admission n = 102	6.5 × 105 (1.08x105–2.96 × 106)	8.10 × 105 (4.74 × 104–3.24 × 106)	5.94 × 105 (1.59 × 105–2.42 × 106)	0.52b	1.0 (1.0–1.0)	0.64
48 h post antibiotics n = 42	2.9 × 104 (3.8x103–2.12 × 105)	2.72 × 104 (4.12 × 103–2.43 × 105)	7.96 × 104 (1.56 × 103–2.19 × 105)	0.64b	1.0 (1.0–1.0)	0.22

^at-test.

^bMann–Whitney-U test.

^cFisher exact test/Chi-squared test.