Table 1. Effective doses of γ-rays and protons to decrease blood cell count by 10% (ED10), 50% (ED50), and 90% (ED90).
Cell Type | Dose Rate | Time after Irradiation | Effective dose (and 95% CI) for γ-rays | Effective dose (and 95% CI) for protons | ||||
---|---|---|---|---|---|---|---|---|
ED10 | ED50 | ED90 | ED10 | ED50 | ED90 | |||
WBCs | High | 3 hours | 0.41 (0.14 – 0.67) | 1.87 (0.66 – 3.10) | 4.21 (1.48 – 6.95) | 0.32 (0.18 – 0.46) | 2.10 (1.17 – 3.03) | 6.96 (3.87 – 10.06) |
Low | 0.91 (0.09 – 1.75) | 6.05 (0.59 – 11.50) | 20.09 (1.97 – 38.21) | NM | NM | NM | ||
High | 48 hours | 0.13 (0.09 – 0.17) | 0.81 (0.55 – 1.08) | 2.50 (1.70 – 3.30) | 0.08 (0.06 – 0.11) | 0.55 (0.37 – 0.72) | 1.82 (1.24 – 2.39) | |
Low | 0.11 (0.07 – 0.15) | 0.72 (0.47 – 0.96) | 2.38 (1.57 – 3.19) | 0.13 (0.09 – 0.18) | 0.88 (0.59 – 1.18) | 2.93 (1.94 – 3.91) | ||
Neutrophils | High | 48 hours | 0.31 (0.11 – 0.52) | 2.04 (0.71 – 3.37) | 6.51 (2.25 – 10.76) | 0.18 (0.08 – 0.28) | 1.19 (0.55 – 1.84) | 3.95 (1.81 – 6.10) |
Low | 0.27 (0.09 – 0.45) | 1.79 (0.61 – 2.98) | 5.96 (2.01 – 9.90) | 0.42 (0.05 – 0.79) | 2.12 (0.26 – 3.98) | 5.03 (0.61 – 9.45) | ||
Lymphocytes | High | 3 hours | 0.05 (0.03 – 0.07) | 0.33 (0.18 – 0.49) | 1.11 (0.60 – 1.63) | 0.05 (0.03 – 0.07) | 0.32 (0.17 – 0.48) | 1.07 (0.56 – 1.58) |
Low | 0.06 (0.03 – 0.09) | 0.41 (0.21 – 0.61) | 1.36 (0.71 – 2.01) | 0.06 (0.03 – 0.10) | 0.41 (0.18 – 0.64) | 1.35 (0.59 – 2.11) | ||
High | 48 hours | 0.05 (0.02 – 0.07) | 0.33 (0.16 – 0.49) | 1.08 (0.55 – 1.62) | 0.08 (0.01 – 0.15) | 0.41 (0.06 – 0.75) | 0.98 (0.15 – 1.80) | |
Low | 0.06 (0.03 – 0.09) | 0.40 (0.21 – 0.59) | 1.33 (0.69 – 1.96) | 0.11 (0.00 – 0.23) | 0.54 (0.00 – 1.11) | 1.25 (0.00 – 2.58) |
High dose rate: 0.5 Gy/minute; low dose rate: 0.5 Gy/hour. Neutrophil counts at 3 hours post-irradiation were not decreased and not included in this table.