Skip to main content
. Author manuscript; available in PMC: 2014 Oct 27.
Published in final edited form as: Gravit Space Res. 2013 Oct;1(1):79–94.

Table 1. Effective doses of γ-rays and protons to decrease blood cell count by 10% (ED10), 50% (ED50), and 90% (ED90).

Cell Type Dose Rate Time after Irradiation Effective dose (and 95% CI) for γ-rays Effective dose (and 95% CI) for protons
ED10 ED50 ED90 ED10 ED50 ED90
WBCs High 3 hours 0.41 (0.14 – 0.67) 1.87 (0.66 – 3.10) 4.21 (1.48 – 6.95) 0.32 (0.18 – 0.46) 2.10 (1.17 – 3.03) 6.96 (3.87 – 10.06)
Low 0.91 (0.09 – 1.75) 6.05 (0.59 – 11.50) 20.09 (1.97 – 38.21) NM NM NM
High 48 hours 0.13 (0.09 – 0.17) 0.81 (0.55 – 1.08) 2.50 (1.70 – 3.30) 0.08 (0.06 – 0.11) 0.55 (0.37 – 0.72) 1.82 (1.24 – 2.39)
Low 0.11 (0.07 – 0.15) 0.72 (0.47 – 0.96) 2.38 (1.57 – 3.19) 0.13 (0.09 – 0.18) 0.88 (0.59 – 1.18) 2.93 (1.94 – 3.91)
Neutrophils High 48 hours 0.31 (0.11 – 0.52) 2.04 (0.71 – 3.37) 6.51 (2.25 – 10.76) 0.18 (0.08 – 0.28) 1.19 (0.55 – 1.84) 3.95 (1.81 – 6.10)
Low 0.27 (0.09 – 0.45) 1.79 (0.61 – 2.98) 5.96 (2.01 – 9.90) 0.42 (0.05 – 0.79) 2.12 (0.26 – 3.98) 5.03 (0.61 – 9.45)
Lymphocytes High 3 hours 0.05 (0.03 – 0.07) 0.33 (0.18 – 0.49) 1.11 (0.60 – 1.63) 0.05 (0.03 – 0.07) 0.32 (0.17 – 0.48) 1.07 (0.56 – 1.58)
Low 0.06 (0.03 – 0.09) 0.41 (0.21 – 0.61) 1.36 (0.71 – 2.01) 0.06 (0.03 – 0.10) 0.41 (0.18 – 0.64) 1.35 (0.59 – 2.11)
High 48 hours 0.05 (0.02 – 0.07) 0.33 (0.16 – 0.49) 1.08 (0.55 – 1.62) 0.08 (0.01 – 0.15) 0.41 (0.06 – 0.75) 0.98 (0.15 – 1.80)
Low 0.06 (0.03 – 0.09) 0.40 (0.21 – 0.59) 1.33 (0.69 – 1.96) 0.11 (0.00 – 0.23) 0.54 (0.00 – 1.11) 1.25 (0.00 – 2.58)

High dose rate: 0.5 Gy/minute; low dose rate: 0.5 Gy/hour. Neutrophil counts at 3 hours post-irradiation were not decreased and not included in this table.