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Structure and function of oxysterols. Structure of the three most potent oxysterols for EBI2: 7α,25-OHC, 7α,27-OHC, and 7β,25-OHC. The potencies (given as EC50 values) of these oxysterols in terms of migration of EBV-infected B cells (blue columns), and of the B-cell lymphoma cell line RS11846 (red columns) 6 are provided together with the potencies determined by GTPγS recruitment in CHO-K1 cells (green columns) 7.
