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. 2014 Oct 27;5:496. doi: 10.3389/fimmu.2014.00496

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Copyright © 2014 Spencer, Bonjour, Melo and Weller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ultrastructure of a tissue human eosinophil undergoing cytolysis. Note the disintegrating nucleus (Nu) and extracellular free secretory granules (Gr) in the surrounding tissue. (Ai, Aii) are boxed areas of (A) seen at higher magnification. Note the presence of free, intact eosinophil sombrero vesicles (EoSVs – highlighted in pink) in the tissue, after cell lysis. Tissue eosinophils were present in a biopsy performed on a patient with inflammatory bowel disease. Scale bar: 800 nm (A); 300 nm (Ai, Aii).