Table 1.
Characteristics of study participants by quintiles of FGF-23: the MESA
| Range | FGF-23 quintiles (pg/mL) |
P-value | ||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||
| <29 | 29–34 | 35–40 | 41–49 | >49 | ||
| N | 1201 | 1182 | 1203 | 1208 | 1183 | |
| Demographics | ||||||
| Age (y) | 60 (10) | 62 (10) | 62 (10) | 62 (10) | 64 (10) | <0.001 |
| Male | 494 (41%) | 549 (46%) | 597 (50%) | 616 (51%) | 580 (49%) | <0.001 |
| Race/ethnicity | ||||||
| White | 378 (32%) | 433 (37%) | 447 (37%) | 506 (42%) | 530 (45%) | <0.001 |
| Chinese | 140 (12%) | 152 (13%) | 169 (14%) | 137 (11%) | 154 (13%) | |
| Black | 355 (30%) | 305 (26%) | 332 (28%) | 297 (25%) | 299 (25%) | |
| Hispanic | 328 (27%) | 292 (25%) | 255 (21%) | 268 (22%) | 200 (17%) | |
| Medical history | ||||||
| Hypertension | 477 (40%) | 475 (40%) | 501 (42%) | 551 (46%) | 625 (53%) | <0.001 |
| Antihypertensive meds | 366 (30%) | 372 (32%) | 403 (34%) | 466 (39%) | 571 (48%) | <0.001 |
| Diabetes | 145 (12%) | 158 (13%) | 134 (11%) | 127 (11%) | 179 (15%) | 0.281 |
| Smoking status | ||||||
| Never | 589 (49%) | 603 (51%) | 612 (51%) | 601 (50%) | 643 (54%) | <0.001 |
| Former | 400 (33%) | 421 (36%) | 435 (36%) | 462 (38%) | 440 (37%) | |
| Current | 207 (17%) | 157 (13%) | 155 (13%) | 140 (12%) | 98 (8%) | |
| Statin use | 149 (12%) | 167 (14%) | 159 (13%) | 191 (16%) | 209 (18%) | 0.002 |
| Measurements | ||||||
| BMI (kg/m2) | 27.7 (5.4) | 27.8 (5.2) | 27.9 (5.3) | 28.8 (5.3) | 28.9 (5.7) | <0.001 |
| SBP (mmHg) | 125 (22) | 125 (21) | 125 (21) | 127 (21) | 128 (22) | <0.001 |
| Total cholesterol (mg/dL) | 193 (34) | 194 (35) | 193 (34) | 195 (36) | 195 (37) | 0.101 |
| HDL cholesterol (mg/dL) | 54 (15) | 51 (14) | 51 (14) | 49 (14) | 50 (14) | <0.001 |
| Triglycerides (mg/dL) | 105 [73, 152] | 107 [77,158] | 107 [74,156] | 118 [84,171] | 122 [84,177] | <0.001 |
| Serum calcium (mg/dL) | 9.61 (0.38) | 9.62 (0.37) | 9.63 (0.38) | 9.68 (0.39) | 9.71 (0.44) | <0.001 |
| eGFR (mL/min/1.73 m2) | 90 (15) | 87 (16) | 85 (16) | 82 (16) | 76 (19) | <0.001 |
| 25-OH vitamin D (ng/mL) | 23 (11) | 25 (11) | 25 (11) | 25 (11) | 28 (12) | <0.001 |
| Intact PTH (pg/mL) | 40 [31, 53] | 40 [31, 51] | 41 [31, 53] | 42 [32, 54] | 41 [32, 55] | 0.064 |
| Serum phosphorous (mg/dL) | 3.61 (0.49) | 3.65 (0.51) | 3.64 (0.50) | 3.68 (0.51) | 3.75 (0.57) | <0.001 |
| eGFR < 60 mL/min/1.73 m2 | 39 (3%) | 48 (4%) | 72 (6%) | 113 (9%) | 218 (19%) | <0.001 |
| ACR ≥ 30 mg/g | 86 (7%) | 86 (7%) | 102 (9%) | 104 (9%) | 163 (14%) | <0.001 |
Data are n (%) for categorical variables, mean (SD) or median [range] for continuous variables, as appropriate.
BMI, body mass index; SBP, systolic BP; DBP, diastolic BP; ACR, urine albumin-to-creatinine ratio; eGFR, estimated GFR.