Table 2.
Cross-sectional associations between cystatin C-based glomerular filtration rate (eGFR) and LVEF, IVRT or MPI at age 70 in PIVUS and ULSAM: multivariable regression, whole cohort with LVEF >40%
| Estimated glomerular filtration rate (eGFR) Whole cohort | ||
|---|---|---|
| β-coefficient (95% CI) | P-value | |
| PIVUS | ||
| Model A; sex and age | ||
| LVEF | 0.11 (0.03 to 0.18) | 0.004 |
| IVRT | −0.12 (−0.18 to −0.05) | 0.001 |
| MPI | −0.10 (−0.17 to −0.03) | 0.006 |
| Model B; DAG-adjusted | ||
| LVEF | 0.10 (0.03 to 0.17) | 0.008 |
| IVRT | −0.07 (−0.14 to −0.01) | 0.02 |
| MPI | −0.07 (−0.14 to 0.0001) | 0.051 |
| ULSAM | ||
| Model A; sex and age | ||
| LVEF | 0.14 (0.04 to 0.23) | 0.005 |
| IVRT | −0.05 (−0.14 to 0.04) | 0.24 |
| MPI | −0.09 (−0.18 to 0.01) | 0.08 |
| Model B; DAG-adjusted | ||
| LVEF | 0.11 (0.02 to 0.21) | 0.02 |
| IVRT | −0.03 (−0.12 to 0.06) | 0.50 |
| MPI | −0.06 (−0.15 to 0.04) | 0.25 |
Data are regression coefficients for a 1-SD higher eGFR.
LVEF, left ventricular ejection fraction; IVRT, isovolumic relaxation time; MPI, myocardial performance index.
Model A: adjusted age, sex. Model B: DAG-adjusted; age, sex, systolic and diastolic blood pressure, BMI, diabetes, LDL-cholesterol and smoking. Whole cohort PIVUS: LVEF (n = 785), IVRT (n = 850), MPI (n = 732); ULSAM: LVEF (n = 407), IVRT (n = 494), MPI (n = 424).