Table 2.

Comparison of logistic regression models for risk of AKI in the sapphire cohort (i) using only clinical variables and (ii) using clinical variables plus [TIMP-2]•[IGFBP7]

Variable	Clinical model		Clinical model plus [TIMP-2]•[IGFBP7]
	Odds ratio (95% CI)	P-value	Odds ratio (95% CI)	P-value
Age	1.02 (0.99–1.04)	0.16	1.01 (0.99–1.04)	0.27
APACHE III (non-renal) score	1.01 (1.00–1.02)	0.070	1.01 (0.99–1.02)	0.39
Hypertension	1.7 (0.8–3.4)	0.14	1.9 (1.0–4.0)	0.066
Nephrotoxic drugs	2.4 (1.2–4.7)	0.011	2.2 (1.1–4.4)	0.029
Liver disease	4.8 (1.9–12.1)	0.001	4.7 (1.7–13.0)	0.003
Diabetes	2.1 (1.1–3.8)	0.02	1.9 (1.0–3.5)	0.053
Sepsis	1.2 (0.6–2.4)	0.56	1.0 (0.5–2.1)	0.96
History of CKD	0.65 (0.26–1.62)	0.35	0.86 (0.32–2.32)	0.77
KDIGO ≥ 1 by creatininea	9.0 (5.0–16.3)	<0.001	5.7 (3.0–10.8)	<0.001
[TIMP-2]•[IGFBP7] >0.3 to ≤2.0*	Not included in model		3.5 (1.6–7.7)	0.002
[TIMP-2]•[IGFBP7] >2.0*	Not included in model		11.7 (4.6–29.4)	<0.001

Models for risk of KDIGO 2 or 3 AKI within 12 h of the first sample collection. All patients with a [TIMP-2]•[IGFBP7] value and data for all clinical variables were included (N = 721). All clinical covariates shown in Table 1 and Supplementary Data Table S2 of Kashani et al. [8] with P-value <0.1 were included. CKD was also included because it is a known risk factor for AKI.

^aKDIGO stage of 1 or greater by serum creatinine criteria at the time of sample collection.

*Overall P-value < 0.001 for [TIMP-2]•[IGFBP7] (likelihood ratio test).