Scheme 7.
Sulfonylation reactions on solid phase. Sulfonates were subsequently modified on solid phase (Scheme 8) or were subjected to TFA cleavage/deprotection and purified and analyzed in aqueous solution.a
a RN′ = Ac-Thr(OtBu)-Tyr(OtBu)-, RC′ = -Asn(Trt)-NHRink-Resin. RN = Ac-Thr-Tyr-, RC = -Asn-NH2.
