Scheme 13.
Substitution reactions on 4R- or 4S-hydroxyproline bromoacetate on solid phase. a
a RN′ = Ac-Thr(OtBu)-Tyr(OtBu)-, RC′ = -Asn(Trt)-NHRink-Resin. RN = Ac-Thr-Tyr-, RC = -Asn-NH2.
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