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. Author manuscript; available in PMC: 2014 Oct 27.
Published in final edited form as: J Am Chem Soc. 2013 Mar 11;135(11):4333–4363. doi: 10.1021/ja3109664

Scheme 17.

Scheme 17

Organometallic reactions on solid phase. Peptides were subjected to TFA cleavage/deprotection, purified, and characterized. Chromatograms for the multistep synthesis of 107 are in Figure 6d. Chromatograms for the multistep synthesis of 109 are in Figure 6ca

a RN′ = Ac-Thr(OtBu)-Tyr(OtBu)-, RC′ = -Asn(Trt)-NHRink-Resin. RN = Ac-Thr-Tyr-, RC = -Asn-NH2.