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. Author manuscript; available in PMC: 2014 Oct 27.
Published in final edited form as: J Am Chem Soc. 2013 Mar 11;135(11):4333–4363. doi: 10.1021/ja3109664

Figure 9.

Figure 9

CD spectra of TYXN peptides indicating the effect of proline substitutions on modulating peptide conformation. (a) Ac-TYPN-NH2; (b) Ac-TYHypN-NH2(1) (red circles) and Ac-TYhypN-NH2(4) (blue squares); (c) Ac-TYFlpN-NH2(27) (red circles) and Ac-TYflpN-NH2(26) (blue squares); (d) Ac-TYP(4R-azido)N-NH2(18) (red circles) and Ac-TYP(4S-azido)N-NH2(21) (blue squares); (e) Ac-TYP(4R-OAc)N-NH2(58) (red circles) and Ac-TYP(4S-OAc)N-NH2(59) (blue squares); (f) Ac-TYP(4-oxo)N-NH2(91); (g) Ac-TYP(4,4-F2)N-NH2(101) and (h) Ac-TYP(4,4-dithiolane)N-NH2(102). CD data were collected in water with 25 mM KF and 20 mM phosphate pH 7.0. CD data were background corrected but were not smoothed. CD spectra with error bars are shown in the Supporting Information.