Figure 2.
Guanfacine (0.1, 0.3 and 1.0 mg·kg−1, i.p.) reduced activity of wild-type (WT) and NK1R−/− mice in both the light zone and dark zone, and reduced crossings between the zones but had no effect on the time spent in either zone. (A) Activity per unit time in the light zone; (B) activity per unit time in the dark zone; (C) number of returns to the light zone; and (D) time in the light zone of a light–dark exploration box. NI, no injection; Veh, vehicle (saline). Data show mean ± SEM, N = 5 per group. Lines linking bars indicate statistical significance of at least P < 0.05 and * indicates P < 0.05 versus vehicle within genotype.