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. Author manuscript; available in PMC: 2014 Oct 27.
Published in final edited form as: Ocul Surf. 2011 Jul;9(3):126–138. doi: 10.1016/s1542-0124(11)70022-2

Table 2.

Ligands that bind TL: (A) extracted from native protein (B) binding in vitro. Reprinted from Redl, 2000

Ligand Kinetic parameters Ref.
(A) Stearic acid ND [28]
Palmitic acid ND [28]
Cholesterol ND [28]
Lauric acid ND [28]
Triacylglycerols ND [28]
Fatty alcohols ND [28]
(B) Retinol Kd ~ 0.6 μM [8]
Oleic acid ND [46]
16-APa Kd ~ 0.8 μM [29]
DAUDAb Ki ~ 2.8 μM [29]
Cholesterol Ki ~ 15.9 μM [29]
Lauric acid Ki ~ 9.1 μM [29]
Palmitic acid Ki ~ 3.2 μM [29]
Stearic acid Ki ~ 1.3 μM [29]
Phosphatidylcholine Ki ~ 1.2 μM [29]
a

16-AP, 16-(9-anthroyloxy)palmitic acid.

b

DAUDA, 11-(5-dimethylamino-1-naphthalenylsulphonyl)amino-undecanoic acid.