Fig. 5.

A hierarchy of mnemonic interference resolution in the medial temporal lobe. The figure illustrates a proposed conceptual model for resolving interference in the medial temporal lobes. The information processing capacities and domain selectivity (object or “nonspatial” processing vs. spatial processing) are based on anatomical connectivity and studies in animals and humans. Given the relative contributions of these regions to the resolution of object and spatial mnemonic interference, we hypothesize that there is an incremental change in domain-selective representational overlap as information proceeds along each pathway to the hippocampal DG/CA3, where representations are multidimensional and maximally separated. The conceptual model amounts to an incremental reduction in mnemonic interference as information projects from domain-selective visual streams into the hippocampus. Critically, there is information exchange at the level of the medial temporal lobe that could potentially integrate information upstream of the hippocampus.