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. 2014 Apr 9;15(5):576–585. doi: 10.1002/embr.201338240

Figure 2. OMA1 is cleaved at residues 443 to 452 and this positively correlates with OPA1 processing.

Figure 2

A OMA1−/− MEFs expressing OMA1-Flag and WT MEFs expressing indicated OMA1 mutation constructs (Flag-tagged) were treated with or without CCCP (20 μM, 4 h) and whole-cell extracts were analyzed by Western blot with the indicated antibodies; “Δ” indicates deletion of residues.

B WT and OMA1−/− MEFs expressing the indicated OMA1 constructs were treated with or without CCCP (20 μM, 4 h) and the cell lysates were assessed by Western blot using the indicated antibodies.

C OMA1−/− MEFs expressing OMA1-Flag or indicated OMA1 mutants were incubated with or without CCCP (20 μM, 4 h) and the whole-cell extracts were probed with the indicated antibodies.

D Lysates from OMA1−/− MEFs expressing OMA1-Flag or OMA1 mutants as indicated treated with or without CCCP (20 μM, 4 h) were analyzed by Western blot using the indicated antibodies.