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. 2014 Apr 15;15(5):518–528. doi: 10.1002/embr.201338271

Figure 2. The activities of NRs are controlled by co-regulators.

Figure 2

Co-activators recruit histone acetyltransferases (HATs) such as CBP/p300 to activate gene expression. Examples of co-activators are SRC family members, RIP140, PGC-1α, MAGED1. Co-repressors, such as SMRT and NCoR, recruit histone deacetylase 3 (HDAC3) to repress gene expression. In addition, canonical circadian clock regulators such as Cry and Per are also important cofactors to regulate the activities of NRs in circadian rhythms and metabolism.