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. 2014 Mar 17;15(5):529–539. doi: 10.1002/embr.201338126

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© 2014 The Authors

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A Left panel, structure of the targeted allele after homologous recombination. Right panel, expression levels of lamin A, progerin, and lamin C protein isoforms in the livers of Lmna^G609G/G609G, Lmna^G609G/+, Lmna^+/+, Lmna^LCS^/+, and Lmna^LCS^/^LCS, determined by Western blotting.

B Left panel, survival curves of male and female Lmna^+/+ (n = 25), Lmna^G609G/+ (n = 27), Lmna^G609G/G609G (n = 25), Lmna^LCS^/+ (n = 21), and Lmna^LCS^/^LCS (n = 32) mice. Right panel, histogram showing the median lifespan of each genotype.

C Body weights of male Lmna^+/+ (n = 11), Lmna^G609G/+ (n = 9), Lmna^G609G/G609G (n = 8), Lmna^LCS^/+ (n = 9), and Lmna^LCS^/^LCS (n = 12) mice. Food intake was measured for 15- and 45-week-old mice (panels below body weight curves).

D Weights of individual organs as a percentage of total body weight for 45-week-old Lmna^G609G/+ (n = 15), Lmna^LCS^/^LCS (n = 8), and Lmna^+/+ (n = 10) mice.

Data information: Results were expressed as median (B) or means (C and D) ± s.e.m. The significance of differences in lifespan was determined with the log-rank (Mantel–Cox) test.