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. 2014 Sep 22;136(41):14365–14368. doi: 10.1021/ja508067c

Table 3. Substrate Scope of Styrenyl Bromides.

graphic file with name ja-2014-08067c_0006.jpg

entry R pdt yield (%)a ee (%)b
1 4-Me-C6H4 5a 83 96
2 4-F-C6H4 5b 74 94
3c 4-Cl-C6H4 5c 66 95
4c 4-CF3-C6H4 5d 49 94
5c 4-OCF3-C6H4 5e 81 94
6c 4-OTBS-C6H4 5f 82 96
7c 4-NMe2-C6H4 5g 55 95
8c 2,3-diMe-C6H3 5h 76 96
9c 3,4-diMeO-C6H3 5i 73 95
10c 4-Bpin-C6H4 5j 59 94
11 4-OH-C6H4 5k 86 93
a

Isolated yield, reactions conducted under N2 on 0.2 mmol scale for 6 h.

b

Determined by SFC using a chiral stationary phase.

c

Run with 15 mol % NiCl2(dme) and 16 mol % L6.